The TrpC7 Antibody: PerCP from MyBioSource.com is a Mouse Monoclonal antibody to TRPC7. This antibody recognizes Human, Mouse, and Rat antigen. The TrpC7 Antibody: PerCP has been validated for the following applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Background Info: Detects ~100kDa.
Scientific Background: Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a non-selective cation channel that is directly activated by DAG. TrpC7 shows constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Because of this, TrpC7 plays an important role in the Ca2+ signaling pathway (3). TrpC7 is also expressed abundantly in the heart, and combined with its ability to act as a Ca2+ channel, TrpC7 might contribute to the process of heart failure (4)